Synthesis, Spectral Characterization and Biological Studies of Coordination Compounds of Ruthenium(iii) with Schiff Bases Derived from Sulpha Drugs

The reactions of ruthenium trichloride with Schiff bases derived from sulpha drugs in 1:2 molar ratio leads to the formation of a new series of coordination compounds of type [Ru(L) 2 (H 2 O)Cl]. The Schiff bases used here are o-Vanillin sulphanilamide (oVSaH), o-Vanillin sulphamerazine (oVSmrzH), salicylaldehyde sulphanilamide (SdSaH), salicylaldehyde sulphamerazine (SdSmrzH), 2-hydroxy-1-naphthaldehyde sulphanilamide (2hNSaH), 2-hydroxy-1naphthaldehyde sulphamerazine (2hNSmrzH). The reactions of ruthenium(III) chloride with Schiff base ligands have been investigated on the basis of elemental analysis, electrical conductance, magnetic susceptibility measurements and spectral (infrared, electronic, H NMR) data. The possible structures have been suggested for the resulting compounds. The Schiff bases used in these studies are condensation products of sulpha drugs, viz. sulphanilamide and sulphamerazine with o-vanillin, salicylaldehyde and 2-hydroxy-1-naphthaldehyde. The disappearance of phenolic proton upon complexation indicates coordination by phenolic oxygen (after deprotonation) and azomethine nitrogen, respectively. The magnetic and spectral studies indicate octahedral geometry for the resulting complexes. The antifungal activity screening against Aspergillus niger and Fusarium solani shows that complexes are more potent in comparison with free ligands.